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COVID-19 vaccine and cancer – latest updates

Hand holding a COVID-19 vaccinemore than 300 different possible vaccines in development, numerous in the final stages of testing.

Now, as initial data is being secreted from different ordeals, anticipation is rising. With vaccine news coming thick and fast, we want to make sure everyone has access to information about the COVID-1 9 vaccine and what it could mean for beings with cancer, so we’ll be informing this blog affix as new data and information emerges.

8 December- Vaccine rollout begins in the different regions of the UK

90-year-old Margaret Keenan has become the first person to receive the Pfizer-BioNTech COVID-1 9 inoculation, as mass rollout begins across the UK.

Healthcare workers, help dwelling workers and trade the over 80 s are likely to be prioritised to receive the inoculation, after it was approved for expend last week.

50 infirmaries in England have been selected to receive the first quantities of the inoculation and hand the first rounds of the vaccination program. Scotland, Wales, and Northern Ireland are also set to begin their vaccination programmes from hospices today.

With the first 800,000 dosages arriving this week, limited quantities will be available until further dosages arrive. To begin, elderly people who are hospital outpatients, as well as those who are being exhausted after a stay in hospital, will be among the first to be offered the vaccine. Each individual will require two pokings, administered within 21 periods of each other, so the initial 800,000 dosages will vaccinate 400,000 parties. Prioritisation radicals are based on who has the greatest risk of becoming seriously ill or dying from the virus.

Others over the age of 80 will be invited to attend the hospital to receive a punch, and caution dwelling providers will be able to book their staff into vaccination clinics. Any appointments not used for these priority radicals will be given to healthcare workers who are at greatest gamble of serious illness from COVID-1 9.

Chris Hopson, chief executive of NHS Providers, has added that those over 80 should not be worried if they have not yet received a letter or telephone calls from the NHS asking them to be injected this month, as the “vast majority” of over 80 s will have to wait until early next year.

” I'm sure there will be communications over the coming few weeks that will tell people how quickly we are getting through the over-8 0s, and there will be plenty of communications to say, at the privilege level, if you haven't had a letter then you should talk to your GP, but we are many weeks away from that ,” Hopson added.

2 December- Pfizer-BioNTech inoculation approved in the UK and to be wheeled out next week

The UK has become the first country to approve the Pfizer-BioNTech vaccine for widespread usage, after the Remedy and Healthcare products Regulatory Agency( MHRA) reconfirmed that the inoculation is safe for rollout across the country.

The chairman and chief executive officer of Pfizer, Albert Bourla, has called this a “historic moment in the fight against COVID-1 9 “. The good news comes after the inoculation has been turned around in just 10 months, a huge improvement on previous endeavours, which typically have covered a decade or more.

The mRNA vaccine, which troubles advocate volunteers up to 95% protection against COVID-1 9, should be available to those who need it most, including elderly and attend residence patients and staff, within the week. Protection from the inoculation should stop people from becoming infirmity with the virus. So far, the UK has 40 million dosages, enough to vaccinate 20 million people, with the first 800,000 quantities arriving early next week.

The JCVI, who established the preliminary priority issues, have exhausted revised advice on priority groups for vaccination, which you can read here. The roll remains the same since it was announced that the “clinically extremely vulnerable” will be residence alongside the over-7 0s.

The JCVI outlined that many individuals who are “clinically extremely vulnerable” will have some degree of immunosuppression or be immunocompromised and may not respond as well to the vaccine. Based on this information, those who are “clinically extremely vulnerable” should continue to follow Government advice on reducing their risk of infection. Deliberation has been given to increasing the priority of those who are household contacts of immunosuppressed someones, nonetheless there is currently no data on the extent to which COVID-1 9 vaccines can foreclose transmission.

The vaccine will be distributed from Pfizer centres in Germany, Belgium and the USA. Approximately 50 hospitals across the country have been prepared to deliver the first of the vaccination curriculum. Specialist vaccination units in spaces such as conference cores are also being set up and some GPs and pharmacists may have access to inoculations, if they have the available cold storage facilities required to store the jab.

To find out more, principal to BBC News.

30 November- Final results from Moderna confirm vaccine is 94% effective

The final results from Moderna’s vaccine visitations verified that their inoculation demonstrated 94% efficacy against COVID-1 9, and none who received the vaccination developed a severe case of the virus.

The recent word has entered into an approving process with regulators around the world who will study the contest data for the inoculation and decide if the data on its safety and effectiveness are robust enough to be recommend for roll out.

The UK has now bought 7 million doses of the vaccine, which are expected to arrive in the UK in March. On surface of that, the UK has pre-ordered 40 million of the Pfizer/ BioNTech inoculation and 100 million of the AstraZeneca Oxford vaccine. Full trial data has still not been been exhausted but you can predicted more about the Moderna vaccine at BBC News and The Guardian.

28 November- Extremely prone given high priority for COVID-1 9 inoculation in UK

The provisional priority issues published under Public Health England has scheduled people aged 18 times and over who are deemed “clinically extremely vulnerable” as the same priority as the over-7 0s to receive a COVID-1 9 inoculation.

People considered “clinically extremely vulnerable” are those who were asked to shield during the course of its pandemic, and include:

People with cancer who are undergoing active chemotherapy Being with lung cancer who are undergoing progressive radiotherapy Person with cancers of the blood or bone marrow such as leukaemia, lymphoma or myeloma who are at any stage of treatment Person having immunotherapy or other continuing antibody managements for cancer People having other targeted cancer treatments that can affect the immune arrangement, such as protein kinase inhibitors or PARP inhibitors People who have had bone marrow or stanch cadre transplants in the last 6 months or who are still take immunosuppression doses

Although this prioritisation list is subject to further potential alters as the vaccine is still waiting endorsement from the Medicines and Healthcare makes Regulatory Agency( MHRA ), those considered “clinically extremely vulnerable” have now been placed in priority radical 4 of 9. Located on these changes, the interim lead, advised by the Joint Committee on Vaccination and Immunisation( JCVI ), says the order of priority should be:

Older adults in a upkeep home and care home works

All those 80 years of age and over and health and social care workers

All those 75 years of age and over

All those 70 years of age and over and the clinically extremely vulnerable souls, omitting pregnant women and those under 18 years of age

All those 65 years of age and over

Adults aged 18 to 65 years in an at-risk group

All those age-old 60 and over

All those 55 and over

All those age-old 50 and over

23 November- Initial results of AstraZeneca-Oxford vaccine announced

The day’s big story was of results from clinical ordeals in Britain and Brazil of the inoculation led by drug company AstraZeneca and researchers in Oxford. The inquiries involved over 20,000 individuals and established differing levels of protectivity depending on how the doses were administered( between 62 and 90% ). Like all the recent develops, these conclusions were announced in a press release and have not yet been independently verified.

COVID-1 9 vaccines in development

There are more than 300 vaccines in developments, countless in the final stages of testing. The vaccines are all aiming to protect people against developing COVID-1 9, but they’re produced in different ways.

The main vaccines that have reported upshots still further are:

The Pfizer-BioNTech vaccine: Contains a minuscule scrap of the virus’s genetic code became in the lab- announced RNA- that codes for an integrated part of the virus called the' spike protein’, which sits on the outside of the virus. When the RNA is injected into the body it can instruct cells to produce these proteins, priming the immune structure to be able to recognise and destroy the coronavirus, without expose the body to the virus itself. This inoculation must be stored at -7 0degC. Moderna vaccine: Like the Pfizer-BioNTech vaccine, the Moderna vaccine contains RNA that codes for the virus’s spike protein. It can be stored under -20 degC( normal freezer temperature) for up to 6 months. Oxford-AstraZeneca vaccine: Contains a diminished anatomy of a harmless virus that is generally causes the common cold in chimpanzees but doesn’t grow in humen. The virus has been modified to include the gene for the coronavirus spike protein protein. Injecting this virus aims to prime the immune method to attack without exposing the body to the full virus. The inoculation can be stored at fridge temperature.

The ordeals explicitly omitted beings with a autobiography of cancer apart from a few exceptions; those with localised prostate cancer( where the cancer is contained in the prostate and has not spread to anywhere else ), non-melanoma bark cancer that has been treated, cervical carcinoma in situ( pre-cancer) that has been treated, or those with a low-grade peril of either their cancer coming back, or spreading to other parts of the body.

So far, we haven’t seen any data about how effective the inoculation was in these beings , nor how many were on the experiments- we’ll be looking out for this information as it emerges.

The UK government has already pre-ordered 100 million dosages of this vaccine.

23 November- Last troubles of COVID-1 9′ antibody cocktail’ therapy begin

In addition to vaccine development, AstraZeneca have started large-scale inquiries of an “antibody cocktail” aimed at give short-term protection to beings with a languished immune structure, who would be unlikely to develop immunity after a inoculation. Antibodies form a key part of the immune system’s response to infection and it’s hoped that these antibodies developed in the lab will help the immune system to fight off the virus. AstraZeneca have described it as “almost like a passive vaccination.”

5, 000 people around the world will be taking part in the contest of this medicine that scientists hope could give individuals immediate defence lasting up to one year. If successful, this may make up part of the UK’s wider COVID-1 9 therapy portfolio and be available to people whose immune organisations are compromised.

Experts react to COVID-1 9 vaccine news

Like most of us, Cancer Research UK-funded professionals have been following the news closely and have called the progress' exceptional’.

News of an effective COVID vaccine is great to hear. Having a vaccine will compile the world safer, which makes it will be safer for beings with cancer more and it will become much easier for cancer treatments to continue.

We look forward to getting a better understanding of the best time to give the vaccine to cancer cases to give them the best level of protection.

– Martin Ledwick, Cancer Research UK's head information nurse

Normal drug or vaccine occurrence would take in the range of 5-10 years, sometimes much more significant, so these developments have been remarkable.

But experts have been keen to emphasise that the rapid turnaround of the COVID-1 9 inoculations isn’t because touchstones have descended. In actuality, the COVID-1 9 trials have involved more parties than standard vaccine trials and have been able to draw on cutting-edge developments in technology and data analysis.

The amazing progress is in part because scientists, governments, the enterprises and academic academies various regions of the world have turned their focus to this one goal. And to further accelerate development, different phases of vaccine trials and product have overlapped.

COVID-19 vaccine development timeline

Copy this relation and share our graphic. Approval: Cancer Research UK.

Finally, while the initial results are extremely promising, it’s early days more. Preliminary data from one vaccine inquiry led by Pfizer recommended the vaccine offered 90% protection against developing COVID-1 9, whilst more recent data discovered the inoculation was 94% effective in over-6 5s. Initial reports from a second vaccine trial made by Moderna disclosed same fleshes .

Experts expect more develops- including important safe data- to materialise in the next 4 to 6 weeks. Vaccination will only be approved once it has passed the usual quality standards to be prepared by the Medical and Healthcare makes Regulatory Agency( MHRA) in the UK.

You can read more about the various COVID-1 9 vaccines in this piece by writer Tom Chivers, who’s taking part in the Oxford-AstraZeneca vaccine trial.

What could a COVID-1 9 vaccine means for parties with cancer?

We’ll be following COVID-1 9 vaccine improvements closely to help us understand a range of things including:

Whether medication could affect the timing of vaccination in people with cancer and when’s the best time to give people with cancer the inoculation to give them the best level of shelter. If people with cancer could respond to the vaccine differently.

Whether people with cancer will be protected by others receive protection( known as' flock immunity ‘) When parties with cancer will be offered the vaccine in the UK. How the different types of vaccine work.

Please comment below if there are any other questions you have about the inoculation.

At this very early stages, there isn’t a huge amount of information about how effective the different inoculations are specifically for beings with cancer.

Why may vaccines be less effective for some people with cancer? Cancer and its medicine can weaken the immune plan, attaining it harder to fight infections like COVID-1 9. It can also change the acces someone’s immune system responds to a inoculation- varying how effective it may be in preventing or reducing the severity of an infection like COVID-1 9.

It should become clearer how the inoculation may work for people with cancer as full is submitted in accordance with clinical ordeals begin to emerge.

Who’s taken part in COVID-1 9 vaccine troubles?

We don’t have information on how many people living with cancer, or with a history of cancer, have been involved in COVID-1 9 inoculation inquiries so far. But some people with cancer have been able to take part in these visitations, although who can take part varies from trial to tribulation.

For example, the earliest phase of the Pfizer trial involved healthful people aged 18 to 55 or 65 to 85. Beings with pre-existing conditions were able to take part as long as they didn’t require a significant change in therapy or hospitalisation for decline cancer in the 6 weeks prior to enrolment.

In later phases of the experiment( phases 2 and 3) the lower senility limit was reduced to 16 year olds and individuals identified as being in a' high-risk’ group based on their use of modes of public transport, being a frontline essential worker or other factors were included. Although people with cancer weren’t explicitly excluded from this list, all those people who immunocompromised or receiving immunosuppressive regiman were not able to take part, and anyone taking part was necessary stable infection prior to enrolment.

For the late chapter troubles of the Oxford vaccine, anyone over the age of 18 who’s considered to be' medically stable’- someone who’s not expected to be hospitalised or conversion their regiman less than 3 months before enrolment- could enrol in the inquiry. The criteria for the Oxford trial explicitly eliminates anyone with a history of cancer, apart from a few cancer categories, or those with a low-pitched threat of either their cancer coming back following curative medication or spreading to other parts of the body.

Another vaccine that’s affect the news recently is the Moderna vaccine. Similar to the Oxford vaccine inquiry, medically stable beings age-old 18 or over were able to take part in the Moderna vaccine troubles. Nonetheless, all those people who immunocompromised or have made immunosuppressive therapies in the 6 months before the experiment were not able to enrol.

Beyond vaccine troubles, studies looking at how people with cancer’s immune systems respond to COVID-1 9 may also provide useful information on if the vaccine will be effective for people with specific types of cancer.

Who will be prioritised to receive the inoculation in the UK?

It’s vital that as vaccines begin to become available, there’s a clear approach to prioritise their implement. This is particularly important as there won’t be enough quantities available for everyone to be vaccinated first.

Although at this stage there has been no formal prioritisation, interim recommendations from the Joint Committee on Vaccination and Immunisation( JCVI ), released in september 2020, afford a provisionalprioritisation list.

At the top of the list are older adults living in care homes and care home laborers, followed by all those aged 80 and over as well as health and social care workers. Priority groups then follow in age order, in accordance with proclamations shaped in the last week following initial vaccine trial answers.

While the coming is largely age located, the prioritisation also includes' at risk’ adults, a broad-minded word that will need clarifying. The JCVI- which cautions UK state agencies- has recognized that some underlying health conditions may result in a higher risk of serious disease and death from COVID-1 9 infection, including some blood cancers.

There will likely be more information on the prioritisation criteria in the coming weeks as governments prepare for vaccine roll out- we will update as soon as it’s liberated.

Lilly, Katie, Angs and Lyndsy

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